Original Contribution Lead Burden and Psychiatric Symptoms and the Modifying Influence of the d-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism The VA Normative Aging Study

نویسندگان

  • Pradeep Rajan
  • Karl T. Kelsey
  • Joel D. Schwartz
  • David C. Bellinger
  • Jennifer Weuve
  • David Sparrow
  • Avron Spiro
  • Thomas J. Smith
  • Huiling Nie
  • Howard Hu
  • Robert O. Wright
چکیده

1 Department of Environmental Health, Harvard School of Public Health, Boston, MA. 2 Bureau of Environmental Disease Prevention, Division of Environmental Health, New York City Department of Health and Mental Hygiene, New York, NY. 3 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA. 4 Center for Environmental Health and Technology, Brown University, Providence, RI. 5 The Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. 6 Department of Neurology, Children’s Hospital, Harvard Medical School, Boston, MA. 7 Veterans Affairs Boston Healthcare System, Boston, MA. 8 Department of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA. 9 Department of Medicine, Boston University School of Medicine, Boston, MA. 10 Department of Epidemiology, Boston University School of Public Health, Boston, MA. 11 Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI. 12 Division of Emergency Medicine, Children’s Hospital, Harvard Medical School, Boston, MA.

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The delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bone and blood lead levels in community-exposed men: the Normative Aging Study.

Recent research has indicated that a polymorphic variant of delta-aminolevulinic acid dehydratase (ALAD) may influence an individual's level of lead in bone and blood and, as a result, may also influence an individual's susceptibility to lead toxicity. In this study, we investigated whether this ALAD polymorphism is associated with altered levels of lead in bone and blood among 726 middle-aged ...

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Delta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).

BACKGROUND AND OBJECTIVE Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this...

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HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEWS δ-Aminolevulinic Acid Dehydratase Genotype and Lead Toxicity: A HuGE Review

The ALAD gene (chromosome 9q34) codes for δ-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24). ALAD catalyzes the second step of heme synthesis and is polymorphic. The ALAD G177C polymorphism yields two codominant alleles, ALAD-1 and ALAD-2, and it has been implicated in susceptibility to lead toxicity. Genotype frequencies vary by geography and race.The rarer ALAD-2 allele has been associ...

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A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead.

Associations between the presence of a constitutional variant of delta-aminolevulinic acid dehydratase (ALAD-2) and lead concentrations in blood and bone, as well as between this allele and indices of kidney function, were investigated among 691 members of a construction trade union. The average blood lead level in this group was 7.78 micrograms/dl. No significant difference was observed in blo...

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تاریخ انتشار 2007